One of the most famous pilgrimage destinations in Italy is certainly the Vatican City, the recommended way to reach the Vatican City starting from Loreto is to take the A14 motorway direction south. Exit at Teramo-Giulianova-Mosciano Sant'Angelo toward Teramo than take the motorway A24 direction Rome l'Aquila Teramo. Continue on this road until you arrive in Rome and here Follow the directions to Vatican City. It takes about 3 hours and 30 minutes Have a nice trip!
Rome - Vatican City
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